Antihistamine Meclizine Herman Ostrow Orofacial Pain and Oral Medicine Wiki

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if meclizine is right for you. Through its antagonistic action on the H1 receptors, meclizine primarily works by inhibiting signaling pathway transduction through histaminergic neurotransmission from the vestibular nuclei and NTS to the CTZ and medullary vomiting center. Meclizine may also decrease the labyrinth excitability and vestibular stimulation.

Another suggests the eyes mostly see the interior of the car which is motionless while the vestibular system of the inner ear senses motion as the vehicle goes around corners or over hills and even small bumps. Therefore, the effect is worse when looking down but may be lessened by looking outside of the vehicle. Common side effects are Drowsiness, dry mouth, and on rare occasions, blurred vision have been reported. Meclizine may trigger drowsiness, fatigue, and dry mouth. In case that happens it is important to immediately contact a physician.

Is Your Medication Making You Tired?

There is limited information regarding Patient Counseling Information of Meclizine in the drug label. There is limited information regarding Meclizine Storage in the drug label. There is limited information regarding Clinical Studies of Meclizine in the drug label.

Disease Interaction

The lowest published toxic dose (TDLo) in rats via the oral route is 800 mg/kg. There is limited information regarding Off-Label Non–Guideline-Supported Use of Meclizine in pediatric patients. There is limited information regarding Off-Label Guideline-Supported Use of Meclizine in pediatric patients. There is limited information regarding FDA-Labeled Use of Meclizine in pediatric patients. There is limited information regarding Off-Label Guideline-Supported Use of Meclizine in adult patients. There are no known interactions between meclizine and foods or drinks.

Cyclizine derivatives

• Meclizine may trigger drowsiness, fatigue, and dry mouth.
• There is limited information regarding Meclizine Storage in the drug label.
• Other drugs may interact with meclizine, including prescription and over-the-counter medicines, vitamins, and herbal products.

Meclizine is most effective if taken before symptoms appear.

• There is limited information regarding Off-Label Non–Guideline-Supported Use of Meclizine in pediatric patients.
• Promethegan is used for allergic reactions, allergic rhinitis, allergies, anaphylaxis, light …
• However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
• Do not drive or do other activities that require alertness or coordination until you know how meclizine affects you.

Drug Images

Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be meclizine wikipedia mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers.

If you are on a dosing schedule, skip any missed dose. You should not use meclizine if you are allergic to it. Be careful if you drive or do anything that requires you to be alert.

WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Meclizine may interact with other medicines and supplements. Before taking meclizine, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Mechanism of action

Tell your healthcare provider if you have any of the following. Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

Meclizine has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours. The most common side effects of meclizine are listed below. Tell your healthcare provider if you have any of these side effects that bother you. Meclizine comes as a regular and chewable tablet and a capsule. For motion sickness, meclizine should be taken 1 hour before you start to travel. For dizziness caused by an ear condition, follow your doctor’s directions.

What should I do if I miss a dose of meclizine?

It is proposed that meclizine may be excreted into breast milk. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol. In addition, the potential for abuse may be increased with the combination. Meclizine may increase the toxicity with CNS depressants, neuroleptics and anticholinergic. Alcohol, sedatives and tranquilizers can increase the drowsiness of the patient. The oral and intraperitoneal LD50 in mouse are 1600 mg/kg and 625 mg/kg, respectively.